EOSC-Life makes data resources from LS RIs ‘FAIR’ and publishes them in the EOSC following guidelines and standards. Overall, this will drive the evolution of the RI repository infrastructure for EOSC and the integration of the LS RI repositories. EOSC-Life implements workflows that cross disciplines and address the needs of interdisciplinary science. Through open hackathons and bring-your-own-data events, we co-create EOSC-Life with our user communities, providing a blueprint for how the EOSC supports widespread and excellent data-driven life science research. EOSC-Life addresses the data policies needed for human research data under GDPR. Interoperable provenance information will describe the history of the sample and data to ensure reproducibility and adherence to regulatory requirements.