22/02/2016 - 26/02/2016 10:00 - 17:30
The paradigm for molecular interpretation of complex events at the cell level has shifted. Large scale genomic profiling of species, including humans, has become commonplace and sequencing technology is no longer a main bottleneck. Sequencing and data analysis are common practice also in medicine, when addressing the problem of the molecular origin of diseases. In the last twenty years Bioinformatics has been helping data storage and analysis. However, the investigation of cell molecular complexity reveals that different hierarchical layers of data integration are necessary for understanding the role of macromolecular crowding and the subtle interplays among environment, cell signalling and regulation of gene expression. The Bologna winter school will investigate the main results of the “omic” era, including new molecular scenarios such as that of the many different types of RNA and their putative roles in the cell functioning. When hierarchical organisation is the problem, new algorithms are necessary to model results and to infer from sequencing data when variations in DNA, RNA and proteins are useful for medical diagnosis. During the school, leading scientists in the field of Bioinformatics will debate to which extent sequencing data are actionable for a better understanding of biological processes.